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Cobix®

Cobix®
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  • General Info

    Description

    Cobix® capsules contain the active chemical compound Celecoxib - a non-steroidal anti-inflammatory drug (NSAID). It is a specific inhibitor of the enzyme cyclooxygenase 2 (COX-2) that is induced during the inflammation process and is responsible for the synthesis of inflammatory chemicals called prostaglandins (PG), particularly PGE2.

    Cobix® capsules are used to treat chronic inflammatory diseases such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis, to reduce pain, inflammation, tenderness, stiffness and swelling in the affected joints.

    Cobix® is also used for the management of acute pain and treatment of dysmenorrhea (menstrual pain) in people who have not been able to achieve sufficient pain relief from other medications.

    This drug should be combined with well balanced but calorie controlled diet rich in fruits, nuts and vegetables.

    Cobix® is also known as Celecoxib, Celebra, Celebrex, Celcoxx, Selecap.

    Dosage

    Cobix® is taken orally with a full glass of water. The medication can be taken either with or without food.

    For treatment of rheumatoid arthritis usual Cobix® dosage is 100-200 mg twice a day.

    For treatment of osteoarthritis usual Cobix® dosage is 100 mg twice a day or 200 mg once a day.

    For treatment of painful menstruation usual Cobix® dosage is 400 mg once a day at the first day of treatment. When needed, the dosage of 400 mg can be divided into double dose and can be taken twice a day.

    For treatment of FAP usual Cobix® dosage 400 mg twice a day.

    If you want to achieve most effective results do not stop taking Cobix® suddenly.

    To decrease the risk of an upset stomach, take Cobix® with a glass of milk or a meal and a full glass of water.

    If the patient cannot swallow the capsule whole, the contents may be opened and sprinkled into a spoonful of applesauce to make swallowing easier.

    Cobix® dosage depends on patient's overall health and other factors.

    Missing a dose

    Do not take a double dose. If you miss a dose you should take it as soon as you remember about the missed dose. If it is the time for the next dose you should continue your regular dosing schedule.

    Overdose

    Symptoms of overdose:

    • lack of energy
    • drowsiness and stomach pain
    • nausea and vomiting
    • hives and rashes
    • vomiting material that is bloody or looks like coffee grounds
    • bloody or black, tarry stools
    • loss of consciousness

    If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your healthcare provider immediately.

    Storage

    Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

  • Safety Information

    Side effects

    Cobix® has side effects. The most common are:

    • upset stomach or stomach pain
    • diarrhoea
    • indigestion
    • bloating wind
    • dizziness
    • sinusitis and upper respiratory tract infection
    • blurred vision
    • skin rash and itching
    • swollen hands, ankles and feet

    Less common but more serious side effects during taking Cobix®:

    • gastric ulceration and bleeding
    • cardiovascular events such as hypertension and heart attack

    Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

    Contraindications

    Do not take Cobix® if you are allergic to celecoxib, aspirin or any other non-steroidal anti-inflammatory drug (NSAID), or any ingredients in Cobix® capsules.

    Do not take Cobix® if you are allergic to sulphonamides.

    Do not take Cobix® if you have an ulcer, gastric bleeding, inflammation of intestines like Ulcerative colitis or Crohn’s disease.

    Do not take Cobix® if you have asthma, breathing problems, nasal congestion, nasal polyps.

    Do not take Cobix® if you have severe kidney or liver disease, heart conditions, history of heart failure or stroke.

    Do not take Cobix® if you have problems with the blood circulation or had a surgery on the arteries in your legs.

    Do not take Cobix® if you are taking medications that interact with Cobix®, including other NSAIDs, aspirin, anticoagulants like warfarin, oral corticosteroids, the antifungal drug fluconazole, diuretics like furosemide, lithium for depression, ACE inhibitors for high blood pressure, antacids for indigestion.

    Cobix® should be used with caution by people with diabetes, high blood pressure, raised levels cholesterol in the blood and by smokers.

    Do not take Cobix® if you are under 18 years of age.

    Do not take Cobix® if you are pregnant or breastfeeding woman.

  • F.A.Q.

    Q: How does Cobix® work?

    A: Cobix® works by inhibiting the formation of chemicals called prostaglandins that cause pain and inflammation, thereby reducing the pain and swelling symptoms.

    Q: Is Cobix® a narcotic or addictive drug?

    A: No. Cobix® is not a narcotic or addictive drug.

    Q: Are there any possible drug interactions?

    A: Ask your doctor to get the full list of the drugs needed to be avoided while taking Cobix® as they may interfere it and may cause adverse effects. Some of them are: Aliskiren, ACE inhibitors, Angiotensin II, Cidofovir, Receptor blockers, Warfarin, Fever, Lithium, Naproxen/ibuprofen, Anti-platelet drugs, Fluconazole, Clopidogrel, Enoxaparin, Corticosteroids.

    Q: How long should you take Cobix®?

    A: You should continue to take your Cobix® capsules for as long as recommended by your doctor, which may take a few days, several weeks or longer to get properly benefitted by the drug, depending on what you are being treated for.

    Q: What are the health risks when taking Cobix®?

    A: Cobix® capsules have been associated with increased risk of gastric ulceration and bleeding and cardiovascular events including heart attack, although these events are rare.

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